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= Van Essen Lab =
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= Van Essen Lab - Wiki Home Page =
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[[Image:LabAboutSurfaceArch.jpg|350px]]            [http://medschool.wustl.edu http://brainvis.wustl.edu/wiki_linked_files/images/wunewlog.bw.jpg]
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[[Image:VElab.gif|350px]]            [http://medschool.wustl.edu http://brainvis.wustl.edu/wiki_linked_files/images/wunewlog.bw.jpg]
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Welcome to the Van Essen Laboratory at the [http://medschool.wustl.edu/ Washington University School of Medicine] in [http://stlouis.missouri.org/ Saint Louis], [http://www.mo.gov/ Missouri], USA.
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Our laboratory develops and uses computerized brain mapping techniques to study the structure, function, and development of cerebral cortex in humans and nonhuman primates.  
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== Cortical Cortography ==
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== Cortical Cortography == Our laboratory developed an integrated software suite for surface-based analyses of cerebral and cerebellar cortex.  This includes: Caret software for visualizing and analyzing many types of experimental data mapped to surfaces and/or volumes; the SumsDB [[Sums:About | SuMS]]database online (WebCaret) [[WebCaret:About | WebCaret]] and offline (Caret) visualization and analysis.
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We have developed an integrated software suite for surface-based analyses of cerebral cortex. This includes [[Caret:About | Caret]] (used for surface reconstruction, visualization, and analysis), [[Sums:About | SuMS]] (a web-accessible database), and surface-based [[Caret:Atlases | atlases]] of macaque and human cortex that contain extensive information about cortical areas, functional organization, and connectivity.
 
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== Neurophysiology ==
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'''Atlases''' of human, macaque, mouse, and rat.  Human atlases include the '''PALS-B12''' (Population-Average, Landmark- and Surface-based) atlas of cerebral cortex and the '''PC-CC''' (PALS-Cerebral, Colin-Cerebellar) atlas.
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[[Image:LabAboutNeurophysiology.jpg]]
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Our physiological studies focus on mechanisms of form processing and pattern recognition in visual cortex of the macaque monkey. We are interested in how neuronal receptive field characteristics are transformed at early and intermediate stages of the visual hierarchy (areas V1, V2, and V4), and in how these transformations contribute to the analysis of surface characteristics and object boundaries
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'''Data mining'''. SumsDB includes 31,000 stereotaxic coordinates (‘foci’) from 1,000 neuroimaging studies amenable to data mining by online [link = xxx] and offline [link = xxx] search tools. 
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== Neural Computation ==
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== Ongoing Research Projects ==
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We are developing a unified mathematical framework for modeling large scale neurobiological systems, including the primate visual system. This framework, developed by Charles Anderson and the Computational Neuroscience Research Group (CNRG), is grounded in well-established principles of signal processing, statistical inference, and good engineering design. It provides a rational and robust strategy for simulating and evaluating the function of a wide variety of specific neural circuits. [http://compneuro.uwaterloo.ca http://compneuro.uwaterloo.ca]
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'''Human Cortical Development''' (collaboration with Terrie Inder, Jeff Neil, Jason Hill, and others).  We study human cortical development in prematurely born infants in order to better understand normal cortical maturation and to characterize cortical abnormalities that correlate with abnormal childhood development.  
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[[Image:HumanCortDev.gif|550px]]
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'''Cortical Structure and Function in Disease'''.  We use surface-based approaches to characterize abnormalities in cortical structure and function in a variety of disease conditions, including autism, schizophrenia, and Williams Syndrome.
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[[Image:CortStruct.gif|350px]]
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Interspecies Comparisons. We use interspecies surface-based registration to compare cortical organization in macaques, humans, and great apes.
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'''Interspecies Comparisons'''. We use interspecies surface-based registration to compare cortical organization in macaques, humans, and great apes. 
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[[Image:Interspecies.gif|350px]]
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'''The Neuroscience Information Framework (NIF)''' [link = xxx] is a collaborative effort, funded by the NIH Blueprint, to provide a ‘one-stop shopping’ portal for a wide variety of neuroscience resources.

Revision as of 17:18, 4 December 2008

Van Essen Lab - Wiki Home Page

wunewlog.bw.jpg


Our laboratory develops and uses computerized brain mapping techniques to study the structure, function, and development of cerebral cortex in humans and nonhuman primates.


== Cortical Cortography == Our laboratory developed an integrated software suite for surface-based analyses of cerebral and cerebellar cortex. This includes: Caret software for visualizing and analyzing many types of experimental data mapped to surfaces and/or volumes; the SumsDB SuMSdatabase online (WebCaret) WebCaret and offline (Caret) visualization and analysis.


Atlases of human, macaque, mouse, and rat. Human atlases include the PALS-B12 (Population-Average, Landmark- and Surface-based) atlas of cerebral cortex and the PC-CC (PALS-Cerebral, Colin-Cerebellar) atlas.

Data mining. SumsDB includes 31,000 stereotaxic coordinates (‘foci’) from 1,000 neuroimaging studies amenable to data mining by online [link = xxx] and offline [link = xxx] search tools.

Ongoing Research Projects

Human Cortical Development (collaboration with Terrie Inder, Jeff Neil, Jason Hill, and others). We study human cortical development in prematurely born infants in order to better understand normal cortical maturation and to characterize cortical abnormalities that correlate with abnormal childhood development.

Cortical Structure and Function in Disease. We use surface-based approaches to characterize abnormalities in cortical structure and function in a variety of disease conditions, including autism, schizophrenia, and Williams Syndrome.


Interspecies Comparisons. We use interspecies surface-based registration to compare cortical organization in macaques, humans, and great apes. Interspecies Comparisons. We use interspecies surface-based registration to compare cortical organization in macaques, humans, and great apes.

The Neuroscience Information Framework (NIF) [link = xxx] is a collaborative effort, funded by the NIH Blueprint, to provide a ‘one-stop shopping’ portal for a wide variety of neuroscience resources.

Personal tools
Sums Database